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Symbol
Name
ID 		Nrg1
neuregulin 1
MGI:96083
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
nervous system phenotype
defasiculated phrenic nerve
decreased radial glial cell number
abnormal muscle spindle morphology
decreased muscle spindle number
increased muscle spindle number
abnormal sympathetic ganglion morphology
absent oligodendrocytes
abnormal Schwann cell morphology
decreased Schwann cell precursor number
decreased Schwann cell number
absent Schwann cells
abnormal motor neuron innervation pattern
abnormal sensory neuron innervation pattern
decreased motor neuron number
decreased sensory neuron number
abnormal proprioceptive neuron morphology
abnormal neuromuscular synapse morphology
abnormal cranial ganglia morphology
abnormal petrosal ganglion morphology
small petrosal ganglion
abnormal trigeminal ganglion morphology
small nodose ganglion
abnormal superior vagus ganglion morphology
abnormal cranial nerve morphology
abnormal glossopharyngeal nerve morphology
abnormal hypoglossal nerve morphology
abnormal trigeminal nerve morphology
abnormal mandibular nerve branching
abnormal mandibular nerve innervation pattern
absent mandibular nerve
absent trigeminal nerve
abnormal vagus nerve morphology
abnormal dorsal root ganglion morphology
small dorsal root ganglion
abnormal spinal nerve morphology
abnormal phrenic nerve morphology
abnormal ventral spinal root morphology
abnormal myelination
hypermyelination
abnormal nerve conduction
abnormal excitatory postsynaptic currents
enhanced long-term potentiation
abnormal prepulse inhibition
abnormal PNS synaptic transmission
abnormal endplate potential
abnormal miniature endplate potential
Availability Mouse Genotype
Nrg1tm1Cbm/Nrg1tm1Cbm
Nrg1tm1Gne/Nrg1tm1Gne
Nrg1tm1Leth/Nrg1tm1Leth *
Nrg1tm1Lwr/Nrg1tm1Lwr
Nrg1tm1Zhou/Nrg1tm1Zhou
Nrg1tm2Cbm/Nrg1tm2Cbm
Nrg1tm1Cbm/Nrg1+
Nrg1tm1Gne/Nrg1+
Nrg1tm1Leth/Nrg1+
Nrg1tm1Lwr/Nrg1+
Nrg1tm2Cbm/Nrg1+ *
Nrg1tm2Zhou/Nrg1+
Nrg1tm4.1Cbm/Nrg1+
Tg(Thy1-Nrg1*I)1Kan/0
Tg(Thy1-Nrg1*III)1Kan/0 *
Nrg1tm1Fej/Nrg1tm1Fej
Tg(Camk2a-cre)#Kln/?  (conditional)		 *
Nrg1tm1Fej/Nrg1tm1Fej
Neurod6tm1(cre)Kan/?  (conditional)		 *
Nrg1tm1Fej/Nrg1tm1Fej
Emx1tm1(cre)Krj/?  (conditional)		 *
Nrg1tm1Fej/Nrg1tm1Fej
Tg(Nes-cre)1Kln/?  (conditional)		 *
Nrg1tm3Cbm/Nrg1tm3Cbm
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Nrg1tm4Cbm/Nrg1tm4.1Cbm
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)		 *
Nrg1tm1Cbm/Nrg1tm3Cbm
Isl1tm1(cre)Tmj/Isl1+  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory